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GIP promotes fatty acid synthesis and glucose uptake in adipose tissue with the development of obesity (Getty-Kaushik et al

Nature (2004) 428(6982):56974

doi:10.1016/j.jaad.2009.11.013

Specifically, disruption of the blood-brain barrier (BBB) is a critical pathologic process of EBI and shows promise as a therapeutic target in ameliorating the detrimental effects of SAH ( Matrix metalloproteinase-9 (MMP-9), a member of zinc- and calcium-dependent proteolytic enzymes family,(Rosell and Lo, 2008) is widely distributed in multiple cell types such as neurons, astrocytes, microglia, and endothelial cells, across the central nervous system (CNS) (Ying et al., 2016)