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Description
In 2018, the Amgen team updated a new invention patent titled "Methods for Treating or Ameliorating Metabolic Disorders Using a Gastric Inhibitory Polypeptide Receptor Antagonist Bound to a Glucagon-Like Peptide-1 Receptor Agonist Fusion Protein (WO2018237095A1)." In this patent, researchers have created a fusion by linking the carboxyl-terminal end of a GLP-1 analog to the amino-terminal end of either the light chain variable region or the heavy chain variable region of an antibody or its functional fragment capable of binding to the GIPR receptor
Kamboj AK, Katzka DA, Vela MF, Yadlapati R, Ravi K
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Cureus 15, e43773
19 25 hours) [ Table 1 ]
