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However, there has been no evaluation regarding its long-term impacts on lipid metabolism or the influence on plasma levels of apoB in nondiabetic individuals with obesity who have experienced weight reduction

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A systematic review and meta-analysis of supervised-exercise training interventions in children and adolescents showed that both aerobic and resistance exercise, at vigorous or moderate-to-vigorous intensities, with a volume of 60 min/session and a frequency of 3 sessions/week, aiming to improve cardiorespiratory fitness and muscular strength had benefits on hepatic fat content reduction in youth [122]

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January 2026: Amgen completed Phase 3 enrollment for MariTide (AMG 133) in the MARITIME-Obesity trial, with interim efficacy data expected in Q3 2026 that will position the monthly injection GLP-1/GIP antagonist as a once-monthly obesity treatment alternative