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Commonly reported issues include: Gastrointestinal Distress: Nausea, vomiting, and diarrhea are common, particularly when starting the medication
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GLP-1 and ghrelin attenuate high glucose/high lipid-induced apoptosis and senescence of human microvascular endothelial cells

duodenal targeting showed strong hormone elevations and fewer GI complaints than gastric delivery

K., Panneerselvam A., Singh K

Soluble fiber can naturally raise GLP-1 levels, as well as lower cholesterol and help people feel more full after eating and reduce their appetite
