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Diabetes, 52, 252259

However, biases and residual confounding inherent to EHR-based research could not be eliminated

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A second lower dose was tested as well to investigate a potential dose dependent effect on receptor binding

A potential cause of the increased nerve size noted in pretreatment recordings in this study may be rundown of the nerve sodiumpotassium pump, which has been implicated in DPN pathophysiology [1], leading to intracellular sodium accumulation and osmotic effects