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Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro

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Discovery of the once-weekly glucagon-like peptide (GLP-1) analogue semaglutide

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We also know that adherence to GLP-1s can be challenging due to their adverse effect profile

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In pregnant rabbits given 0.2, 2, 22, 156, or 260 mcg/kg/day exenatide during fetal organogenesis, irregular fetal skeletal ossifications were observed at 2 mcg/kg/day, a dose yielding systemic exposure up to 12-times the human exposure from the MRHD of BYETTA based on AUC comparison

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