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Phase 3 trials are underway with potential approval in 2027

This is where medications targeting GLP-1 and glucose-dependent insulinotropic peptide (GIP) pathways may provide additional benefit

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A reasonable approach for higher-risk patients such as those taking metformin, older adults, or those with very low dietary intake would be to recheck B12 levels at six to twelve months and annually thereafter

In this sense, running or walking becomes a healthy, sustainable way to manage both weight and emotional wellness, making it easier to stick to your goals in the long run. Shubrook agrees, but points out that diet may play a bigger role in weight loss than exercise

doi:10.1016/j.bcp.2015.03.011