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In obese women with the absence of ovulatory dysfunction, infertility has been documented as well [84]
It is conceivable that metformin may be able to potentiate or strengthen the vascular protective effects of GLP-1 and its analogues

No statistically significant differences were observed for other neurodegenerative outcomes, including vascular dementia or Parkinsons disease

Its plausible that the data has not yet revealed an increased risk of thyroid cancer, which can take a long time to develop

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