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Exceeding 6-12 months of use may have undesired effects by increasing LDL cholesterol and cardiovascular risk in some studies, but others have found no difference [50,51,52,53]

Battelino T, Danne T, Bergenstal RM, et al

In the SURPASS clinical trial program, patients treated with Tirzepatide experienced: HbA1c reductions up to 2.5% Weight loss up to 22.5% of body weight in some trials These numbers surpass those seen in many existing diabetes medications and even some weight loss drugs

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Patients with persistent thirst despite GLP-1 therapy may need evaluation for inadequate glycemic control