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You may feel healthier and wear a smaller size, yet still struggle with an abdominal fold, loose upper arms, flattened breasts or skin that gathers around your waist and thighs

FIGURE 15 Additionally, examination of publication bias indicated a symmetrical distribution in the funnel plot, suggesting the absence of publication bias

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When the researchers compared the three groups, they found that the enterocytes (intestinal cells) of the non-berberine HFD group secreted significantly less GLP-1 than the healthy controls

These effects can be shown in vitro in human skin tissue samples [122], and further studies need to be done to determine the extent to which this anti-glucocorticoid effect occurs in vivo