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The advantages of these options include more affordability and flexibility, especially for those without insurance

The longevity of use of these older medications is a testament to their efficacy, but they did have some side effects perhaps most-notably an allergic reaction to sulpha drugs

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[DOI] [PubMed] [Google Scholar] 101.Gallwitz B., Bohmer M., Segiet T., Molle A., Milek K., Becker B., Helsberg K., Petto H., Peters N., Bachmann O

This aligns better with clinical needs, especially given the shared pathophysiology between OSA and cardiovascular/metabolic disorders