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Given the results of the GRADE study and our recent findings suggesting that persistence with GLP-1 RA is associated with better glycemic control than DPP4i, a need exists to understand the comparative durability of the new-generation GLP-1 RA semaglutide and the commonly used glucose-lowering agent class DPP4i in the real-world setting

Our team has compiled some of the most common questions we hear in the clinic to help you get a better understanding of this impressive weight loss aid

Too much water and you are injecting larger volumes for the same dose

One current example of polypharmacology in the clinic is Eli Lillys investigational drug Retatrutide, which acts as a triple agonist against glucagon, GIP, and GLP-1 receptors (Figure 1), engendering even greater weight loss in clinical trials than approved blockbuster drugs Semaglutide (GLP1-R agonist) and Tirzepatide (dual GLP1-R/GIP agonist)

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