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Emerging physiological and clinical evidence suggests that testosterone plays a central role in skeletal muscle anabolism through pathways involving muscle protein synthesis, satellite cell activation, and androgen receptor-mediated transcriptional signaling

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56 This may be the secret of the extraordinary efficacy of tirzepatide, but it is still possible that the best ratio of GLP-1 and GIP activity in a dual agonist has not been discovered

Diabetes Obes Metab 2010;12(3): 204209

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