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Dehydration is another important consideration

You can speak to your GP, who can refer you to NHS Tier 2 community-based weight management services if your BMI is 30 or above (or 27.5 or above for some ethnic groups), or to Tier 3 specialist services for higher BMI with obesity-related conditions

Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsboll T, Warren ML, Bain SC

Although no formal contraindication exists for combining these interventions, the safety and efficacy of this combination have not been studied in clinical trials

Persistent glucose variability increases oxidative stress and inflammatory signaling

Clinical trials have shown that patients on these medications can lose up to 15-20% of their body weight, a result previously achievable only through bariatric surgery