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Here's a simple breakdown: Yerba mate has polyphenols

Efficacy and safety of dapagliflozin in patients with acute heart failure

just one dissolvable tablet a day

Philippaert K, Pironet A, Mesuere M et al (2017) Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

At a 20mg/mL concentration, maintenance doses stay in the comfortable range: 8mg requires 0.4mL (40 units) and 12mg requires 0.6mL (60 units)

NICE Technology Appraisal guidance (TA875 for semaglutide/Wegovy and TA664 for liraglutide/Saxenda) recommends these medications for weight management in adults with: A body mass index (BMI) of at least 35 kg/m and At least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, or non-alcoholic fatty liver disease) For liraglutide (Saxenda), NICE TA664 specifies additional criteria including prediabetes (HbA1c 42-47 mmol/mol or fasting plasma glucose 5.5-6.9 mmol/L) or high risk of cardiovascular disease