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Studies on semaglutide tolerability have consistently shown that GI side effects are most common and most severe during the first few days after each dose increase, when drug levels are climbing toward a new peak

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Jensen L, Kupcova V, Arold G, Pettersson J, Hjerpsted J

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Results were presented graphically