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After a 4-week screening period, participants were randomly assigned, 1:1:1:1:1, to once-weekly 2.5 mg, 5 mg, 10 mg or 15 mg VK2735 or placebo for 13 weeks

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Based on the studies, it appears that the length of time that you take these medications matters

In this study, Chintan Dave, PhD, a researcher at Rutgers University, and colleagues included claims data from 161,489 adults aged 18 to 65 years with type 2 diabetes who were newly prescribed a GLP-1 receptor agonist, 122,114 who started a SGLT2 inhibitor, and 86,047 who started a DPP4 inhibitor

GLP-1 receptors are present not only in the pancreas but also in the central nervous system and cardiovascular tissues