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Although there are data in animal models supporting that this is true, particularly in diet-induced obese mice, in which brown adipose tissue activity is regulated [8], there is no convincing evidence that this occurs in humans [6]
For most people, GI side effects settle well before full benefits of medication take effect.
Accessed July 11, 2025
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Then 10mg
Report suspected side effects through the MHRA Yellow Card scheme (available online or via the Yellow Card app), which helps regulatory authorities monitor medication safety across the UK population
