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Eligibility criteria for study selection We included studies that assessed adult men (aged 18 years) with functional hypogonadism associated with obesity or type 2 diabetes

These hormonal imbalances can impair sperm production and function, diminishing the likelihood of conception

It belongs to a class of medications known as GLP-1 receptor agonists

It could be stress, caffeine timing, or the metabolic shift itself

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For selective Cre-dependent viral targeting, we used Glp1r -Cre mice (C57BL/6 background) 55