retatrutide mechanism gip glp-1 glucagon triple agonist Schematic illustration of monoagonists, dual agonists and Targeting GLP-1, GIP & GCG
Description
The initial dosing regimen of semaglutide subcutaneous injection is 0.25 mg weekly, with the dose increased up to 2 mg for Ozempic and 2.4 mg for Wegovy , respectively, usually after one month at the previous dose

10.1053/j.gastro.2007.03.054 10 BarreraJ

The Wegovy pill needs to be taken on an empty stomach
Can J Diabetes 2020;44:592-6

Semaglutide concurrently improves vascular and liver indices in patients with type 2 diabetes and fatty liver disease

Notably, we found a significant increase in nausea events among participants receiving GLP-1RAs compared to those treated with metformin or placebo