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Endocrine 89 , 680685 (2025)

LDN: A Versatile Gerotherapeutic Low Dose Naltrexone works primarily through its immunomodulatory and anti-inflammatory effects: Mechanism of Action (MOA): Blocks toll-like receptor 4 (TLR4), reducing pro-inflammatory cytokine release (e.g., IL-6) Increases endorphin levels, promoting immune balance and cellular repair Enhances mitochondrial function by reducing oxidative stress While many patients respond well to LDN, some may require additional support to address complex metabolic and inflammatory issues