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Description
A popular weight-loss drug is among those being reviewed in the UK after being linked to reports of suicidal or self-harming thoughts within patients

Weight Loss, Body Composition, and Perceived Changes Significant weight lossparticularly reduction of visceral and subcutaneous adipose tissue in the abdominal and pelvic regionscan lead to noticeable changes in body contour and the appearance of external genitalia

doi: 10.1152/ajpendo.00094.2021

While not commonly reported with Pendulum specifically, people sensitive to gut-brain interactions may notice temporary mood fluctuations during the adjustment period

Starting too aggressive can cause: Different GI effects than you're used to Unexpected energy fluctuations Appetite changes that don't match your tirzepatide experience Give yourself one week at your starting dose to see how the glucagon piece hits you specifically

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