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In the central nervous system, proglucagon and proglucagon-derived peptides (GLP-1, glucagon-like peptide-2, GLP-2, and oxyntomodulin, OXM) are only present in a small group of neurons in the nucleus tractus solitarius (24, 25)

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To optimize therapeutic outcomes, a personalized medicine approachtailoring treatment based on individual pathophysiology and lifestyle factorsis essential
Obstructive sleep apnea and obesity: a review of epidemiology, pathophysiology and the effect of weight-loss treatments

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