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Body composition shifts

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Short-chain fatty acids (SCFAs) produced by gut bacteria through activation of the G protein-coupled free fatty acid receptors FFAR2 (GPR43) and FFAR3 (GPR41) induce GLP-1 Secretion [159]

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Encourage the body to burn stored energy and support fat-oxidation pathways

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Most patients see the best results when they stick to the full 12-week plan

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Regulatory Approvals/Commercial Semaglutide is a GLP-1 analog, developed in 2012 by Novo Nordisk, as a longer acting alternative to liraglutide

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Clinical trials suggest retatrutide may produce progressive appetite suppression and meaningful body weight reduction over time at 5mg dose

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