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Discontinuation appears to be multifactorial, with contributors including gastrointestinal side effects (3), treatment cost and access, patient expectations, and tolerability over time

Most cardiovascular benefits have been observed in GLP-1RAs, such as semaglutide, liraglutide, and dulaglutide

Glucagon-like peptide-1 receptor agonists (GLP-1RA) have emerged as promising agents to improve outcomes in patients with heart failure with preserved ejection fraction (HFpEF) and obesity

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doi: 10.1210/jc.2008-1008 104 PivonelloRDe MartinoMCCappabiancaPDe LeoMFaggianoALombardiGet al

Naltrexone is a medication previously aproved for the treatment of narcotic and alcohol dependency