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Trends Endocrinol metabolism: TEM (2020) 31(6):41021

Excessive muscle loss can reduce metabolic rate, potentially making weight maintenance more challenging, and may impair physical function, particularly in older adults or those with limited muscle reserves at baseline

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Drucker D.J

I see every day how harmful that stigma is, and how it stops people from getting care that could change their health and their lives

It is an argument that effectiveness is the product of pharmacology AND real-world adherence