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If gastrointestinal symptoms significantly impair quality of life or prevent medication adherence despite conservative management, healthcare providers may consider dose adjustment, alternative agents with potentially different side effect profiles, or referral to a gastroenterologist for specialized evaluation

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Harris J.J., Jolivet R., Attwell D

Cefalu WT, Kaul S, Gerstein HC, Holman RR, Zinman B, Skyler JS, et al

Evidence from large renal and cardiovascular outcome trials including the FLOW trial for semaglutide suggests potential kidney-protective effects in people with type 2 diabetes and CKD, including reductions in proteinuria

Townsend RR, Machin I, Ren J, Trujillo A, Kawaguchi M, Vijapurkar U, Damaraju CV, Pfeifer M

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