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During this time, some patients may see a slight reduction in appetite, while weight loss is often modest

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1 In a landmark 72-week NEJM trial , non-diabetic participants lost approximately 15.0% to 20.9 % of their body weight based on doses varying from 5mg, 10 mg, and 15 mg

The World Health Organisation says 2.5 billion adults are overweight (a BMI of 25 or over) or obese (BMI over 30), with this figure predicted to tip to over 50 per cent of the worlds population by 2035

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10 Accordingly, brain uptake and distribution could be likely explanations for the difference in weight-loss efficacy between liraglutide and the larger GLP-1R agonists