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Liraglutide, a widely used GLP-1RA in clinic, ameliorated the macrophage accumulation in periodontitis, by decreasing M1 macrophages but not M2 macrophages (30 g/kg/day) (34)

The occurrence of GI AEs has led some clinicians to question whether the weight loss observed with semaglutide treatment may be primarily a result of these side effects [52]

Hamersky CM, Fridman M, Gamble CL, Iyer NN