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Compared with other second- or third-line glucose-lowering medications, the GLP-1RAs demonstrated a lower rate of adverse CVEs, including heart failure (HR 0.88

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- - - A new Oxford meta-analysis (P04.009, EASO 2025) confirms what many clinicians have observed: stopping GLP-1 receptor agonists often leads to rapid and near-complete weight regain within 12 years