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Discontinuation rate: Only 1-2% stop during this period Psychological state: Highly motivated, visible results drive continued adherence Key achievement: Halfway to goal with strong momentum Weeks 25-36: The Steady State Phase (12mg Maintenance) Starting Weight Week 25: ~182 pounds | Expected Weight Week 36: 174-178 pounds | Net Loss This Period: 4-8 pounds | Total Loss: 42-46 pounds Whats Happening Physiologically Metabolic adaptation intensifies

In another double blind trial (PIONEER 6) which focused on cardiovascular outcomes, 3,183 patients with diabetes and obesity (mean BMI 32.3) were treated for 16 months

This means the constant mental chatter about snacks or cheat meals simply disappears, making it easier to stop nighttime cravings

Semaglutide and tirzepatide partially mitigated this decline, whereas PG-102 more effectively preserved body weight, countering the metabolic deterioration (Fig

The combination of caloric deficit plus training demands places enormous stress on muscle tissue