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Therefore, comprehensive assessment including medical history, lab investigations, and body-composition analysis is necessary before starting treatment

To overcome this limitation, scientists have developed GLP-1 receptor agonists (GLP-1 RAs), such as semaglutide, tilpotide, etc., which extend the half-life to the weekly formulation level through structural modification, achieving sustained regulation

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In addition estrogens are also involved in the regulation of energy expenditure and food intake and have been reported to protect pancreatic cells from various injuries as well as enhancing insulin biosynthesis through activation of the estrogen receptor (74)