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Table 1: Retatrutide Binding Affinity (Ki values) Table 2: Retatrutide Functional Potency (EC50 values) The binding kinetics reveal that retatrutide exhibits highest affinity for the glucose-dependent insulinotropic polypeptide receptor, with a human Ki value of 0.057 nM, representing exceptional binding strength [6] [7] [8]

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There is evidence from in vitro and in vivo studies that GLP-1R activation might have neuroprotective and anti-inflammatory properties by reducing the inflammatory response

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