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An ongoing phase 3 trial, the SELECT study, will evaluate the cardiovascular benefit of semaglutide beyond blood glucose control, as the study population is composed of individuals who are overweight or obese without diabetes [81]
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Most patients who are going to respond well to Qsymia hit this benchmark

Studies have shown that injecting GLP-1 into the brains of mice causes mice to lose their appetite
Changes in Fat Distribution Research suggests HRT may help prevent abdominal fat gain, supporting metabolic health
Metab 46 , 101090 (2020)