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Removal of the first 14 residues of GLP-1 yielded a peptide with 1500-fold lower affinity than GLP-1 and with antagonist properties, while removal of the C-terminal 11 residues resulted in undetectable binding and activity (Gallwitz et al ., 1990)

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Those with neuropathy may not receive normal pain signals to alert them to cuts or blisters, and if untreated, such injuries can become severely infected, possibly even requiring amputation