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SGLT-2 Inhibition with Dapagliflozin reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes: further augmentation of the effects with saxagliptin, a DPP4 inhibitor

However, they point out that their study design reduces the biases common to observational studies and the findings are likely to be generalisable to wider populations

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Both are available without insurance, membership fees, or prior authorization, and both qualify for HSA/FSA accounts, making personalized GLP-1 therapy accessible to patients across all 50 states

Here might be the reasons: 1

The request is aligned with previous communication between Orexo and the FDA, the company noted in its press release, and Orexo has already completed such a study