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Theres also another factor at play: GLP-1 medications often slow gastric emptying , which can create a feeling of fullness that lasts longer

Meta-analyses of clinical trials show that GLP-1 RAs, particularly semaglutide, lead to moderate but clinically meaningful reductions in body weight among adolescents with obesity

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Moreover, GLP-1 RAs slow gastric emptying, thereby blunting postprandial glucose and lipid excursions, though diminished tolerance to this effect may develop during prolonged administration of extended-release preparations

He explained that broader motility issues changes in how food moves through the digestive system are more common

As clinicians continue to address the growing overlap between obesity, diabetes, and chronic pain, GLP-1 therapies are attracting attention as a potentially broader metabolic intervention