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In the study by Noyan-Ashraf et al

While not a formal contraindication, clinicians generally defer initiation of tirzepatide until patients with hyperthyroidism are euthyroid, as overlapping symptoms and cardiovascular effects could complicate assessment of medication tolerance and efficacy

Melanie Cree, a pediatric endocrinologist and director of the University of Colorado Anschutz PCOS clinic, tells Yahoo