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Are there alternative treatments if my clinician advises against GLP-1 medications (for example, due to personal/family history suggesting MTC/MEN2)

[DOI] [PMC free article] [PubMed] [Google Scholar] 2

GLP-1 medications like semaglutide cause significant weight loss, but up to 39% of that loss can come from lean mass rather than fat

The role of hormones in appetite regulation is depicted in Fig

GLP-1 injections require more planning

For a patient who presents with type two diabetes and obesity, it really is appropriate to go to a GLP one, if not as first line therapy, certainly second line therapy, potentially along with an SGLT2 after metformin