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The ongoing dedicated ophthalmic trial named as FOCUS study, which aims to evaluate semaglutides long-term effects on diabetic retinopathy, is now ongoing and could contribute to a comprehensive understanding of the true risk-benefit profile of these agents in patients with or at risk for diabetic retinopathy (NCT03811561) [104]

When to Stop Semaglutide if Planning Pregnancy Medical guidelines suggest discontinuing semaglutide 2-3 months before attempting pregnancy

Bioscience, Biotechnology, and Biochemistry , 74(4), 641645

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230,231 GLP-1 RAs also have positive effects on endothelial function, including increasing nitric oxide production, allowing for increased blood flow, decreasing vascular stiffness, and providing nutrients that are delivered to a specific repair area