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Description
The additive effect appears strongest in individuals with insulin resistance, where metformin's mechanism directly addresses a core metabolic defect

The appetite suppression and caloric restriction achieved with GLP-1 treatment create an energy deficit that the body addresses by mobilizing stored fat throughout the body, including visceral depots

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Similar a otras enfermedades crnicas, el tratamiento farmacolgico a largo plazo puede ser necesario y apropiado

This helps ensure all providers understand the full picture and reduces the risk of interactions with other medicines

Probably, but with some potency reduction depending on ambient temperature
