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They activate GLP-1 receptors, which then results in: Slowed gastric emptying , so you feel full for a longer period of time Decreased food noise in your brain, thereby increasing the feeling of satiety Enhanced insulin release from your pancreas, thereby lowering the amount of blood sugar in your body The weight loss benefit from these medications was found to be substantial, so in 2014, the first GLP-1 agonist (liraglutide branded as Saxenda) was approved for weight loss in non-diabetics

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References National Academies Press (US)

This provides sustained amino acid release throughout the night, supporting muscle maintenance during sleep