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doi: 10.3389/fphys.2017.00595 Received 01 May 2017 Accepted 02 August 2017 Published 24 August 2017 Volume 8 - 2017 Edited by Plcido Navas, Universidad Pablo de Olavide, Spain Reviewed by Jos Manuel Villalba Montoro, Universidad de Crdoba, Spain

Another important consideration is that our IC/BPS cohort was comprised exclusively of female patients to minimize any gender-dependent variability

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Clinicians and patients should not assume the full safety profile yet unless the medication receives FDA approval