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Chronic knockdown of LH GLP-1R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight and ultimately resulted in a doubling of fat mass in males and females

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Retatrutide is currently in the process of entering larger, phase 3 clinical trials, which are expected to be completed by late 2025.