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however, comparative studies indicate that continuous positive airway pressure (CPAP) remains significantly more effective than liraglutide when used as monotherapy.[45] Two recent randomized controlled trials involving 469 participants without diabetes and with moderate to severe OSA demonstrated a 55% reduction in AHI with tirzepatide treatment.[17] These findings led to FDA approval of tirzepatide for moderate to severe OSA in December 2024

When we performed a positive control with T2D using the nine tool variables screened, the MR-PRESSO Outlier test found that rs114977861 and rs1929899 were outlier instrumental variables (Supplementary Table 4), so we excluded them

Biomed Pharmacother (2019) 113:108667

Liraglutide in type 2 diabetes mellitus: Clinical pharmacokinetics and pharmacodynamics

This work was led by Frederick Banting, a Canadian surgeon with the support of John McLeod, a physiologist and expert in diabetes

Overcoming these challenges could lead to long-term healthcare savings and improved overall health outcomes