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Notably, the effectiveness and safety of lixisenatide are virtually not affected in moderate renal insufficiency patients [52]

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Limitations of the study Dependency on preclinical evidence, few large-scale clinical experiments, and translational disparities between animal and human systems limit approval of microneedles in diabetic neuropathy

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It is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

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