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Anti-Inflammatory Benefits Chronic low-grade inflammation, often called "inflammaging," accelerates muscle loss and increases disease risk in older women

Nutritional risk during GLP-1 therapy is primarily intake-driven rather than malabsorptive in origin

Contribution of GIPR agonism The GIPR is expressed in numerous locations throughout the body that potentially impact the metabolic processes that govern glycemic control and body weight (Figure 4) 55

NF-kappaB regulation in the immune system

Additionally, tirzepatide acts on central appetite regulation pathways, promoting satiety and reducing caloric intake, which contributes to its weight loss effects

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