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Thyroid Function The FDA label for semaglutide includes a black box warning about thyroid C-cell tumors, based on animal studies

Practical tips Select a gliptin when modest HbA1c lowering (~0.7 %) is enough and weight gain or hypoglycaemia must be avoided

Early research results on bone health and the use of GLP-1s are mixed, with some randomized trials and meta-analyses suggesting neutral or modestly protective effects on bone density and fracture risk

Sex- and gender-related differences in obesity: from pathophysiological mechanisms to clinical implications

DOI: 10.1056/NEJMe2409972

Medicare Part D typically does not cover semaglutide for weight loss, only for diabetes, leaving millions of older adults with limited affordable options