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Some insurance companies list GLP-1 medications used for weight loss as a coverage exclusion, which means that even if a patient meets FDA-approved criteria and would benefit from using the medication, the plan will not pay for the medication, she says

Evidence indicates that GLP-1RAs preserve mitochondrial function by enhancing calcium uptake, improving membrane potential, increasing ATP production, promoting mitochondrial biogenesis, and reducing oxidative stress and apoptosis (172,173)

First developed in the early 2000s to treat type 2 diabetes by mimicking the action of the naturally occurring hormone glucagon-like peptide 1, GLP-1 receptor agonists have since been shown to have a positive and significant impact on obesity, other medical conditions and biological functions

There were no serious or severe adverse events (AEs) reported, nor discontinuations due to AEs (Table S10)

For example, both triple agonists retatrutide and HM15211 have shown promising results

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