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While Del Rosario and colleagues have attempted to elucidate the activation process of Piezo2 through a dual G-protein interaction approach [33], the detailed molecular mechanism by which Piezo2 senses mechanical force and functions remains to be unraveled

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Tirzepatide added GIP receptor activation to GLP-1, demonstrating that multi-receptor approaches could enhance weight loss without proportionally increasing side effects

Mollema ED, Snoek FJ, Pouwer F, Heine RJ, van der Ploeg HM

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Despite the significant burden of disease, effective pharmacological options remain limited, leaving lifestyle interventions based on dietary modification and physical activity as the mainstay of clinical management [6]